HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-{4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazin-1-yl}propylamine → 3-Phenyl-N-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]isoxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-{4-[2-(2,2,2-Trifluoroethoxy)phenyl]piperazin-1-yl}propylamine | HCID 10567490 | — |
| Reactant | 3-(4-Fluoro-phenyl)-isoxazole-4-carboxylic acid | HCID 23447885 | — |
| Reactant | 1-(3-Aminopropyl)-4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]piperazine | HCID 23447911 | — |
| Product | 3-Phenyl-N-[3-[4-[2-(2,2,2-trifluoroethoxy)phenyl]-1-piperazinyl]propyl]isoxazole-4-carboxamide | HCID 23447905 | 88% |
Reaction Steps
The title compound was prepared according to the procedure described in Example 8, but substituting compound 15B for Compound 8D and Compound 12B for Compound 8B. Purification by flash chromatography (ethyl acetate-2 N ammonia in methanol 95:5) yielded the title product (88%). M.p. 94.5-95.6° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680319B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-2f0d0ab6333548c3af9eebd81fb90316 |
| Source note | uspto-grants-2004_01 |