2,3-Dichlorophenyl Isothiocyanate → N-[4-Chloro-2-hydroxy-3[N'',N''-dimethylaminosulfonyl]phenyl]-N'-(2,3-dichlorophenyl)thiourea

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A solution of N,N-dimethyl-3-amino-6-chloro-2-hydroxybenzenesulfonamide (356 mg, 1.42 mmol) and 2,3-dichlorophenylisothiocyanate (318 mg, 1.57 mmol) in 1.0 mL of N,N-dimethylformamide was stirred at room temperature for 3 hours. Purification by column chromatography on silica gel, eluting with ethyl acetate/hexane (30/70, v/v) to give the desired product (440 mg, 68%). EI-MS (m/z) 455.5 (M+).

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