HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 131724298, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Phenylthiourea | HCID 676454 | — |
| Reactant | HCID 131724299 | HCID 131724299 | — |
| Product | HCID 131724298 | HCID 131724298 | 45.4% |
Reaction Steps
Following the general procedure for protected phenyl thiourea formation outlined in example 1, N-(2-bromophenyl)-N′-[4-chloro-2-hydroxy-3-(N″-tetrahydroisoxazylaminosulfonyl)phenyl]thiourea (627 mg, 1.24 mmol), tert-butyldimethylsilyl chloride (934 mg, 6.2 mmol) and imidazole (169 mg, 2.48 mmol) were reacted to form the desired product (350 mg, 45%). EI-MS m/z 622 (M+) .
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-5f11f4581148499cbcf3f3ecbe6548ca |
| Source note | uspto-grants-2004_01 |