Cyanamide → HCID 178455104, compound

Participants

Reaction Steps

Following the general procedure for cyanoguanidine formation outlined in example 1, N-(2-bromophenyl)-N′-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N″-tetrahydroisoxazylaminosulfonyl)phenyl]carbodiimide (385 mg, 0.79 mmol), cyanamide (133 mg, 3.16 mmol) and N,N-diisopropylethylamine (127 mg, 0.95 mmol) were reacted, followed by desilylation with Cesium fluoride (144 mg, 0.95 mmol) to form the desired product (100 mg, 26%). EI-MS m/z 515 (M+).

Provenance & Evidence