HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanamide → HCID 178455105, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanamide | HCID 9864 | — |
| Reactant | Cesium fluoride | HCID 25953 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 131724303 | HCID 131724303 | — |
| Reactant | HCID 178418324 | HCID 178418324 | — |
| Product | HCID 178455105 | HCID 178455105 | 40% |
Reaction Steps
Following the general procedure for cyanoguanidine formation outlined in example 1, N-(2,3-dichlorophenyl)-N′-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N″-tetrahydroisoxazylaminosulfonyl)phenyl]carbodiimide (547 mg, 0.95 mmol), cyanamide (159 mg, 3.8 mmol) and N,N-diisopropylethylamine (150 mg, 1.14 mmol) were reacted, followed by desilylation with Cesium fluoride (174 mg, 1.14 mmol) to form the desired product (190 mg, 40%). LC-MS m/z 504.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-8b7ee7f6d67e4d6bae9c25e441ca3860 |
| Source note | uspto-grants-2004_01 |