HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-isothiocyanatobenzene → N-[4-Chloro-2-hydroxy-3-[N'',N''-dimethylaminosulfonyl]phenyl]-N'-(2-bromophenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-isothiocyanatobenzene | HCID 611654 | — |
| Reactant | N,N-Dimethyl-3-amino-6-chloro-2-hydroxybenzenesulfonamide | HCID 23447758 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[4-Chloro-2-hydroxy-3-[N'',N''-dimethylaminosulfonyl]phenyl]-N'-(2-bromophenyl)thiourea | HCID 10183328 | 22.1% |
Reaction Steps
A solution of N,N-dimethyl-3-amino-6-chloro-2-hydroxybenzene sulfonamide (480 mg, 3.58 mmol) and 2-bromophenylisothiocyanate (0.53 μL, 3.94 mmol) in 10 mL of ethanol was stirred at room temperature for overnight. Purification by column chromatography on silica gel, eluting with ethyl acetate/hexane (gradient elution) gave the desired product (368 mg, 22%). EI-MS (m/z) 463.67, 465.66, 467.65, 468.64 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-a20d9a8e97254a5c972e6e49909868eb |
| Source note | uspto-grants-2004_01 |