HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 178486147, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Phenylthiourea | HCID 676454 | — |
| Reactant | HCID 23447787 | HCID 23447787 | — |
| Product | HCID 178486147 | HCID 178486147 | 49% |
Reaction Steps
Following the general procedure for protected phenyl thiourea formation outlined in example 12, N-[4-chloro-2-hydroxy-3-(N″,N″-dimethylaminosulfonyl)phenyl]-N′-(2-chlorophenyl)thiourea (500 mg, 1.19 mmol), tert-butyldimethylsilyl chloride (897 mg, 5.95 mmol) and imidazole (162 mg, 2.38 mmol) were reacted to form the desired product (311 mg, 49%). EI-MS m/z 535.32 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-793c0ddf29f34afdb72e0efaea1ab409 |
| Source note | uspto-grants-2004_01 |