HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 87433036, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Phenylthiourea | HCID 676454 | — |
| Reactant | HCID 23447744 | HCID 23447744 | — |
| Product | HCID 87433036 | HCID 87433036 | 45% |
Reaction Steps
Following the general procedure for protected phenyl thiourea formation outlined in example 12, N-[4-chloro-2-hydroxy-3-(N″,N″-dimethylaminosulfonyl)phenyl]-N′-(2-trifluoromethylphenyl)thiourea (416 mg, 1.0 mmol), tert-butyldimethylsilyl chloride (750 mg, 5.0 mmol) and imidazole (136 mg, 2.0 mmol) were reacted to form the desired product (250 mg, 45%). EI-MS m/z 568.0 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-ec117852fc5e4d16b6dea0c0f53625a7 |
| Source note | uspto-grants-2004_01 |