Imidazole → HCID 23447742, compound

Participants

Reaction Steps

Following the general procedure for protected phenyl thiourea formation outlined in example 12, N-[4-chloro-2-hydroxy-3-(N″,N″-dimethylaminosulfonyl)phenyl]-N′-(2-fluorophenyl)thiourea (440 mg, 1.09 mmol), tert-butyldimethylsilyl chloride (817 mg, 5.45 mmol) and imidazole (148 mg, 2.18 mmol) were reacted to form the desired product (387 mg, 69%). EI-MS m/z 518.2 (M+).

Provenance & Evidence