HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 23447818, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | Phenylthiourea | HCID 676454 | — |
| Reactant | HCID 23447801 | HCID 23447801 | — |
| Product | HCID 23447818 | HCID 23447818 | 65% |
Reaction Steps
Following the general procedure for protected phenyl thiourea formation outlined in example 12, N-[4-chloro-2-hydroxy-3-(N″,N″-dimethylaminosulfonyl)phenyl]-N′-(2,3-difluorophenyl)thiourea (418 mg, 1.0 mmol), tert-butyldimethylsilyl chloride (745 mg, 5.0 mmol) and imidazole (136 mg, 2.0 mmol) were reacted to form the desired product (347 mg, 65%). EI-MS m/z 536.2 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-cad4486a128a4c2b9ac6542e6a8ffdf6 |
| Source note | uspto-grants-2004_01 |