Cyanamide → HCID 178486151, compound

Participants

Reaction Steps

Following the general procedure for cyanoguanidine formation outlined in example 12, N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N″,N″-dimethylaminosulfonyl)phenyl]-N′-(2,3-difluorophenyl)carbodiimide (340 mg, 0.68 mmol), cyanamide (114 mg, 2.72 mmol) and N,N-disopropylethylamine (106 mg, 0.82 mmol) were reacted, followed by desilylation with Cesium fluoride (124 mg, 0.82 mmol) to form the desired product (10 mg, 3.4%). EI-MS m/z 430.0 (M+). 1H NMR (DMSO-d6) δ 2.87 (s, 6H), 7.21 (m, 3H), 7.30 (m, 1H), 7.54 (d, 1H), 9.2 (s, 1H), 10.54 (s, 1H).

Provenance & Evidence