Cyanamide → HCID 178486152, compound

Participants

Reaction Steps

Following the general procedure for cyanoguanidine formation outlined in example 12, N-[4-chloro-2-tert-butyldimethylsilyloxy-3-(N″,N″-dimethylaminosulfonyl)phenyl]N′-(2-chloro4-fluorophenyl)carbodiimide (420 mg, 0.81 mmol), cyanamide (136 mg, 3.24 mmol) and N,N-diisopropylethylamine (126 mg, 1.62 mmol) were reacted, followed by desilylation with Cesium fluoride (148 mg, 1.62 mmol) to form the desired product (180 mg, 50%). EI-MS m/z 446.2 (M+).

Provenance & Evidence