Triethylamine → HCID 23447843, compound

Participants

Reaction Steps

To a solution of 2-tert-butyl-6-chloro-benzooxazole-7-sulfonyl chloride (5.54, 18 mmol) and triethylamine (2.51 mL, 18 mmol) in THF (100 mL) at 0° C. was added homopiperazine-carboxylic acid tert-butyl ester (3.0 g, 15 mmol). The reaction was warmed to room temperature and allowed to stir overnight. The solution was concentrated and then diluted with water and extacted with ethyl acetate (3 times). The combined organic layers were dried with MgSO4, filtered, and concentrated. Flash chromatography (80% ethyl acetate/20% Ethanol) on silica gel gave the title compound (4.0 g, 61%). LC-MS m/z 473.2.

Provenance & Evidence