HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67534017, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2-Tert-butyl-6-chlorobenzoxazole-7-sulfonyl chloride | HCID 23447791 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67534017 | HCID 67534017 | 73.3% |
Reaction Steps
Following the general procedure for the synthesis of sulfonylamides outlined in example 51, 2-tert-butyl-6-chlorbenzooxazole-7-sulfonyl chloride (5.0 g, 16.2 mmol), triethylamine (2.4 mL, 17.2 mmol), and piperazine-carboxylic acid tert-butyl ester (3.62 g, 19.4 mmol) were reacted in THF (50 mL) to afford the title compound (5.44 g, 67%). LCMS m/z 402(M−H)+ (desired -Boc).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-71748405b4944c94b78c6e063f1aa7ba |
| Source note | uspto-grants-2004_01 |