HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 6-Amino-3-chloro-2-(piperazine-1-sulfonyl)-phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Benzoxazole | HCID 9228 | — |
| Reactant | HCID 67534017 | HCID 67534017 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Amino-3-chloro-2-(piperazine-1-sulfonyl)-phenol | HCID 23447821 | 97.2% |
Reaction Steps
Following the general procedure for the hydrolysis of the benzooxazole to the desired aniline outlined in example 51, 4(2-tert-butyl-6-chloro-benzooxazole-7-sulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (2.0 g, 4.3 mmol), water (3.65 mL), and H2SO4 (3.65 mL) in 1,4-dioxane (60 mL) were reacted to afford the title compound (1.22 g, 96%). LCMS m/z 292(M−H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680317B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-f3db9c92957f45a5a2421d4ad07762d1 |
| Source note | uspto-grants-2004_01 |