HCID 23448012, compound → HCID 10137794, compound

Participants

Reaction Conditions

Reaction Steps

23 mg. of 11-chloro-6-(2-dimethylamino-ethylamino)-3-methoxy-5,10-diaza-benzo[c]fluoren-7-one (Example 27e) was suspended in N,N-dimethylethylenediamine (2.0 ml) and the mixture was stirred at 60° C. overnight under nitrogen. The solution was diluted with dichloromethane and washed with saturated ammonium chloride aqueous solution and dried over anhydrous sodium sulfate and evaporated to dryness. The residue was purified by silica gel thin layer chromatography developed by dichloromethane-methanol-25% ammonia solution=100:5:1. The desired product was obtained as a dark red powder (17 mg). ESI−MS: m/z 435 (MH+); 1H-NMR (CDCl3): δ2.27 (6H, s), 2.34 (6H, s), 2.60-2.66 (4H, m), 3.60 (2H, q-like, J=6.6 Hz), 3.75 (2H, q-like, J=6.3 Hz), 3.96 (3H, s), 5.76 (1H, brt, J=ca 6 Hz), 6.84 (1H, dd, J=2.6 Hz, 9.6 Hz), 6.92 (1H, d, J=4.6 Hz), 7.04 (1H, d, J=2.6 Hz), 7.36 (1H, brt, J=ca 6 Hz), 8.27 (1H, d, J=4.6 Hz), 8.49 (1H, d, 9.6 Hz).

Provenance & Evidence