Tributyltin Chloride → HCID 23447644, compound

Participants

Reaction Steps

Tri-n-butylstannyl chloride (0.969 ml) and 5.66 ml of a 1.0 N lithiumbis(trimethylsilyl)amide/THF solution were added to a solution of 636 mg of 7-(6-azidohexyl)thioimidazo[5,1-b]thiazole in 20 ml of THF at −40° C. under an argon atmosphere. The mixture was stirred for 45 min. An aqueous ammonium chloride solution was added to the reaction solution, and the mixture was extracted with ethyl acetate, followed by washing with brine. The organic layer was dried over anhydrous magnesium sulfate. The solvent was then removed by distillation, and the residue was purified by column chromatography on silica gel (hexane:ethyl acetate=2:1) to prepare 1.01 g of the title compound.

Provenance & Evidence