7-Acetylthioimidazo[5,1-b]thiazole → HCID 86587269, compound

HRID 1840437Notes

Reaction equation

HRID 1840437 reaction equation
C([S:4][C:5]1[N:6]=[CH:7][N:8]2[CH:12]=[CH:11][S:10][C:9]=12)(=O)C.[N:13]([CH2:16][C@@H:17]([O:20][Si:21]([CH2:26][CH3:27])([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:18]O)=[N+:14]=[N-:15]>>[N:13]([CH2:16][C@@H:17]([O:20][Si:21]([CH2:26][CH3:27])([CH2:24][CH3:25])[CH2:22][CH3:23])[CH2:18][S:4][C:5]1[N:6]=[CH:7][N:8]2[CH:12]=[CH:11][S:10][C:9]=12)=[N+:14]=[N-:15]

Participants

3

Reactant 2

HCID 226316637-Acetylthioimidazo[5,1-b]thiazoleHCID 86587270HCID 86587270, compound

Product 1

HCID 86587269HCID 86587269, compoundYield 85.2%

Procedure

The procedure of Synthesis Example 11b) was repeated, except that 907 mg of 7-acetylthioimidazo[5,1-b]thiazole and 1.27 g of (2R)-3-azido-2-triethylsilyloxy-1-propanol was used as the starting compound. Thus, 1.44 g of 7-((2R)-3-azido-2-triethylsilyloxypropyl)thioimidazo[5,1-b]thiazole was prepared.

Workup

  1. customThe procedure of Synthesis Example 11b)

Sources & evidence

ORD record
ord-11cd10b6c9514aaf8ad14523ae7ad3ff
Source dataset
uspto-grants-2004_01
Patent number
US06680313B2

Reaction notes

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