HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1840474Generated: October 25, 2026
Piperidine → 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one
https://huagongshe.com/reaction/1840474
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| Reactant | 5-Methylindolin-2-one | HCID 5325716 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydroindol-2-one | HCID 53755378 | 74% |
Reaction Steps
A mixture of 5-methyl-2-oxindole (59 mg), 3-methylindole-2-carbaldehyde (56 mg) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90° C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in a vacuum oven for overnight to give 72 mg (74% yield) of 5-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06680335B2 |
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| Source dataset | uspto-grants-2004_01 |
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| ORD ID | ord-1d51a663e20045518c97d3c68929ba5c |
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| Source note | uspto-grants-2004_01 |
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