関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| 反応物 | 2-Oxoindoline-5-sulfonamide | HCID 10198232 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide | HCID 53976496 | 71% |
反応手順
A mixture of 5-aminosulfonyl-2-oxindole (84 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90° C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 88 mg (71% yield) of 3-(3-methyl-1H-indol-2-ylmethylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid amide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06680335B2 |
|---|
| 出典データセット | uspto-grants-2004_01 |
|---|
| ORD ID | ord-a77670fd823947dfa5be7e6cb08166e2 |
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| 出典メモ | uspto-grants-2004_01 |
|---|
