Methylamine → N-methyl-2-oxoindoline-5-sulfonamide

Participants

Reaction Steps

A suspension of 5-chlorosulfonyl-2-oxindole (3.38 g) (prepared as described in Compound IN-02) in 2 M methylamine in tetrahydrofuran (10 mL) was stirred at room temperature for 4 hours at which time a white solid was present. The precipitate was collected by vacuum filtration, washed twice with 5 mL of water each time and dried under vacuum at 40° C. overnight to give 3.0 g (88% yield) of 5-methylaminosulfonyl-2-oxindole.

Provenance & Evidence