HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1840485Generated: October 26, 2026
Piperidine → 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one
https://huagongshe.com/reaction/1840485
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| Reactant | 5-acetyl-2,3-dihydro-1H-indol-2-one | HCID 10219643 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one | HCID 53819303 | 75% |
Reaction Steps
A mixture of 5-acetyl-2-oxindole (70 mg), 3-methylindole-2-carbaldehyde (56 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (30 mg) in ethanol (1 mL) was heated in a sealed tube at 90° C. for overnight. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in oven for overnight to give 83 mg (75% yield) of 5-acetyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06680335B2 |
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| Source dataset | uspto-grants-2004_01 |
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| ORD ID | ord-91fa80a776eb4affb8cab047b9c65bf2 |
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| Source note | uspto-grants-2004_01 |
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