HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1840493Generated: November 3, 2026
Piperidine → 3-(1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one
https://huagongshe.com/reaction/1840493
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Indole-2-carboxaldehyde | HCID 96389 | — |
| Reactant | Oxindole | HCID 321710 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one | HCID 53991611 | — |
Reaction Steps
A mixture of 2-oxindole (133 mg), indole-2-carbaldehyde (174 mg) (prepared according to Synthetic Communications, 1993, 23, 3109) and piperidine (10 mg) in ethanol was heated in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in vacuum oven for overnight to give 3-(1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06680335B2 |
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| Source dataset | uspto-grants-2004_01 |
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| ORD ID | ord-d7fa71a8f8384150906219a38a1660f6 |
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| Source note | uspto-grants-2004_01 |
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