HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1840502Generated: November 1, 2026
Piperidine → 4-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one
https://huagongshe.com/reaction/1840502
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-Methyl-1H-indole-2-carbaldehyde | HCID 277260 | — |
| Reactant | 4-Methyl-1,3-dihydro-2H-indol-2-one | HCID 12579382 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one | HCID 54480851 | — |
Reaction Steps
A mixture of 4-methyl-2-oxindole (147 mg) (prepared as described in Compound IN-015), 3-methyl-indole-2-carbaldehyde (190 mg) (prepared according to Synthetic Communications, 1986, 16, 1799) and piperidine (10 mg) in ethanol was heated in a sealed tube at 95° C. for 4 hours. The mixture was cooled to room temperature. The solid was collected by vacuum filtration, washed with cold ethanol and dried in vacuum oven for overnight to give 4-methyl-3-(3-methyl-1H-indol-2-ylmethylene)-1,3-dihydro-indol-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06680335B2 |
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| Source dataset | uspto-grants-2004_01 |
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| ORD ID | ord-cb317e17ae114a4f94297f88a1349ea7 |
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| Source note | uspto-grants-2004_01 |
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