Diethyl Ether → Methyl 4-[(acetylsulfanyl)methyl]oxane-4-carboxylate

Participants

Reaction Steps

A solution of Intermediate 4 (3.05 g) in DMF (20 ml) was treated with potassium thioacetate (1.47 g) at room temperature for 18 h, then the brown solution was added to 5% sodium bicarbonate solution and extacted with ether (3×200 ml). The solvent was washed with water (200 ml) and brine, dried over MgSO4 and evaporated to give the title compound (2.42 g) as a white solid.

Provenance & Evidence