Benzyl chloroformate → HCID 86590129, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.8 g (10.0 mmol) of methyl (S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-5-pyrid-4-ylpent-4-ynoate and 0.28 g of active 10% palladium-on-charcoal in 20 ml of ethanol is stirred for 3 hours at room temperature under 60 psi of hydrogen. The reaction mixture is filtered and concentrated under reduced pressure. The residue obtained is taken up in 20 ml of acetic acid and stirred for 14 hours in the presence of 0.05 g of platinum oxide, under 60 psi of hydrogen. The reaction mixture is filtered and then concentrated under reduced pressure. The residue obtained is taken up in 10 ml of tetrahydrofuran (THF) and 5 ml of water. This solution is cooled to 0° C., followed by addition of a solution of 3.4 g (40.0 mmol) of sodium hydrogen carbonate in 40 ml of water, and 1.63 ml (12.0 mmol) of benzyl chloroformate are added dropwise. The mixture is allowed to warm to room temperature and the reaction is continued for 4 hours. The reaction mixture is taken up in 200 ml of ethyl acetate and is washed twice with 100 ml of 1N hydrochloric acid solution and then with 100 ml of saturated sodium hydrogen carbonate solution and with 100 ml of saturated sodium chloride solution. The resulting solution is dried over sodium sulphate. The resulting product is filtered and concentrated. The residue obtained is purified by chromatography on a column of silica gel, eluting under pressure with a cyclohexane/ethyl acetate gradient of from 95/5 to 80/20. 3.55 g of methyl (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(phenylmethoxy)carbonyl]piperidine-4-pentanoate are obtained in the form of a viscous oil.

Provenance & Evidence