HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 178465576, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethanimidic acid, ethyl ester, hydrochloride (1:1) | HCID 2724290 | — |
| Reactant | HCID 23447403 | HCID 23447403 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178465576 | HCID 178465576 | 105.7% |
Reaction Steps
To a solution of 1-(4-aminobenzyl)-4-(6-chloro-naphthalene-2-sulfonyl)-2-piperazinone hydrochloride (233 mg) in methanol (20 ml) were added ethyl acetimidate hydrochloride (618 mg) and triethylamine (0.836 ml), and the mixture was stirred at room temperature overnight. The solvent was concentrated and purified with CHP20 column chromatography (water:acetonitrile:1 N hydrochloric acid=70:30:1) to give pale yellow amorphous of the title compound (134 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06680312B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-cba2ec019ece4bf7a49960d60653e34c |
| Source note | uspto-grants-2004_01 |