HCID 69929472, compound → HCID 69930827, compound

HRID 1840590Notes

Reaction equation

HRID 1840590 reaction equation
[CH2:1]([O:8][CH2:9][C@@H:10]1[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:14]=[CH:13][N:12]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([N:30]3[CH:34]=[CH:33][N:32]=[CH:31]3)=[CH:26][CH:25]=2)[C:11]1=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C.[Pd]>[CH2:1]([O:8][CH2:9][C@@H:10]1[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:14][CH2:13][N:12]([CH2:23][C:24]2[CH:29]=[CH:28][C:27]([N:30]3[CH:34]=[CH:33][N:32]=[CH:31]3)=[CH:26][CH:25]=2)[C:11]1=[O:35])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 69929472HCID 69929472, compound

Product 1

HCID 69930827HCID 69930827, compoundYield 89.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In ethanol (80 ml) was dissolved (S)-3-benzyloxymethyl-4-(tert-butoxycarbonyl)-1-[4-(1H-imidazol-1-yl)benzyl]-2-oxo-1,2,3,4-tetrahydropyrazine (1.13 g), and to the solution was added 10% palladium on carbon (1 g). The mixture was subjected to catalytic reduction for 9 hours with medium pressure reduction apparatus, and the catalyst was removed. The solvent was evaporated under reduced pressure to give colorless amorphous of the title compound (1.02 g).

Workup

  1. customthe catalyst was removed
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9636cc85f41e42a595c109ce09b0dc26
Source dataset
uspto-grants-2004_01
Patent number
US06680312B2

Reaction notes

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