HRID1840623

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc(CN2C(=O)N([C@@H](CC3CC3)C(=O)N[C@H](C)CC(=O)O)C(=O)C2(C)C)ccc1NC(=O)Nc1ccccc1C

HCID9960205

未命名化合物

结构：COc1cc(CN2C(=O)N([C@@H](CC(C)C)C(=O)O)C(=O)C2(C(F)(F)F)C(F)(F)F)ccc1NC(=O)Nc1ccccc1C

HCID87951373

未命名化合物

PRODUCTS

生成物

结构：COc1cc(CN2C(=O)N([C@@H](CC(C)C)C(=O)N[C@H](C)CC(=O)O)C(=O)C2(C(F)(F)F)C(F)(F)F)ccc1NC(=O)Nc1ccccc1C

HCID12044603

未命名化合物

PROCEDURE

实验过程

The title compound was prepared as described in Examples 1f and 1g from 500 mg (0.809 mmol) of (S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetic acid of the formula

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-efdde58b7cbc436d928c353cf2227e3c
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06680333B2
来源说明: uspto-grants-2004_01

反应 SMILES

CC1(C)C(=O)N([C@@H](CC2CC2)[C:9]([NH:11][C@H:12]([CH3:17])[CH2:13][C:14]([OH:16])=[O:15])=[O:10])C(=O)N1CC1C=CC(NC(NC2C=CC=CC=2C)=O)=C(OC)C=1.[F:44][C:45]([F:86])([F:85])[C:46]1([C:81]([F:84])([F:83])[F:82])[C:50](=[O:51])[N:49]([C@@H:52]([CH2:56][CH:57]([CH3:59])[CH3:58])C(O)=O)[C:48](=[O:60])[N:47]1[CH2:61][C:62]1[CH:67]=[CH:66][C:65]([NH:68][C:69]([NH:71][C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][C:73]=2[CH3:78])=[O:70])=[C:64]([O:79][CH3:80])[CH:63]=1>>[F:44][C:45]([F:85])([F:86])[C:46]1([C:81]([F:83])([F:82])[F:84])[C:50](=[O:51])[N:49]([C@@H:52]([CH2:56][CH:57]([CH3:59])[CH3:58])[C:9]([NH:11][C@H:12]([CH3:17])[CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:48](=[O:60])[N:47]1[CH2:61][C:62]1[CH:67]=[CH:66][C:65]([NH:68][C:69]([NH:71][C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][C:73]=2[CH3:78])=[O:70])=[C:64]([O:79][CH3:80])[CH:63]=1