(r)-3-((s)-2-(4,4-Dimethyl-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-methylpropionic acid → (r)-3-((s)-2-(4,4-Bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxy-benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl) acetylamino)-3-methylpropionic acid
반응식
CC1(C)C(=O)N([C@@H](CC2CC2)[C:9]([NH:11][C@H:12]([CH3:17])[CH2:13][C:14]([OH:16])=[O:15])=[O:10])C(=O)N1CC1C=CC(NC(NC2C=CC=CC=2C)=O)=C(OC)C=1.[F:44][C:45]([F:86])([F:85])[C:46]1([C:81]([F:84])([F:83])[F:82])[C:50](=[O:51])[N:49]([C@@H:52]([CH2:56][CH:57]([CH3:59])[CH3:58])C(O)=O)[C:48](=[O:60])[N:47]1[CH2:61][C:62]1[CH:67]=[CH:66][C:65]([NH:68][C:69]([NH:71][C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][C:73]=2[CH3:78])=[O:70])=[C:64]([O:79][CH3:80])[CH:63]=1>>[F:44][C:45]([F:85])([F:86])[C:46]1([C:81]([F:83])([F:82])[F:84])[C:50](=[O:51])[N:49]([C@@H:52]([CH2:56][CH:57]([CH3:59])[CH3:58])[C:9]([NH:11][C@H:12]([CH3:17])[CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:48](=[O:60])[N:47]1[CH2:61][C:62]1[CH:67]=[CH:66][C:65]([NH:68][C:69]([NH:71][C:72]2[CH:77]=[CH:76][CH:75]=[CH:74][C:73]=2[CH3:78])=[O:70])=[C:64]([O:79][CH3:80])[CH:63]=1참가 물질
3
반응물 2
HCID 9960205(r)-3-((s)-2-(4,4-Dimethyl-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(cyclopropylmethyl)acetylamino)-3-methylpropionic acid
HCID 87951373(s)-2-(4,4-Bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetic acid생성물 1
실험 절차
The title compound was prepared as described in Examples 1f and 1g from 500 mg (0.809 mmol) of (S)-2-(4,4-bis(trifluoromethyl)-3-(4-(3-(2-methylphenyl)ureido)-3-methoxybenzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetic acid of the formula
출처 및 근거
- ORD 기록
- ord-efdde58b7cbc436d928c353cf2227e3c
- 출처 데이터셋
- uspto-grants-2004_01
- 특허 번호
- US06680333B2
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