2,6-Dichloro-3-methylaniline → 2,6-Dichloro-3-methylaniline

Participants

Reaction Steps

4.4 g (0.025 mol) of 2,6-dichloro-3-methylaniline are heated to 110° C., 1.8 g (0.01 mol) of 5-amino-3-chlorosulfonyl-1,2,4-triazole are added under argon and the suspension is stirred for 6 hours at this temperature. After work-up similar to example 1,2.9 g (99.3% purity) of 2,6-dichloro-3-methylaniline and 2.21 g (96.1% purity) of 5-amino-N-(2,6-dichloro-3-methylphenyl)-1,2,4-triazole-3-sulfonamide are obtained. The theoretical yield is found to be 68.6%, and based on unrecovered aniline the yield is 80.5% of the theory.

Provenance & Evidence