Tert-butyl 4-(bromomethyl)benzoate → HCID 69891455, compound

HRID 1840720Notes

Reaction equation

HRID 1840720 reaction equation
Cl.[CH3:2][NH:3][C@@H:4]([C:8]([OH:10])=[O:9])[CH:5]([CH3:7])[CH3:6].Br[CH2:12][C:13]1[CH:25]=[CH:24][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:15][CH:14]=1>>[CH3:2][N:3]([CH2:12][C:13]1[CH:14]=[CH:15][C:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=[CH:24][CH:25]=1)[C@@H:4]([C:8]([OH:10])=[O:9])[CH:5]([CH3:7])[CH3:6]

Participants

3

Reactant 2

HCID 11414578Tert-butyl 4-(bromomethyl)benzoateHCID 56777029HCID 56777029, compound

Product 1

HCID 69891455HCID 69891455, compoundYield 74%

Procedure

Prepared by reaction of methyl D-valine hydrochloride and tert-butyl 4-bromomethylbenzoate analogously to Example 56, stage a. The compound was obtained in 74% yield after chromatographic purification, FAB-MS: 321 (M+).

Workup

  1. customThe compound was obtained in 74% yield
  2. customafter chromatographic purification, FAB-MS

Sources & evidence

ORD record
ord-35b47deae30a454db3a9fb9feba93972
Source dataset
uspto-grants-2004_01
Patent number
US06683055B1

Reaction notes

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