HRID1840722

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3C[C@@H]12

HCID178418840

未命名化合物

结构：C=C1c2c(Cl)ccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@H]12.O=C(O)c1cc(S(=O)(=O)O)ccc1O

HCID178421622

未命名化合物

PRODUCTS

生成物

结构：C=C1c2c(Cl)ccc(O)c2C(=O)C2=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3[C@@H](O)[C@H]12

HCID178421621

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A rapidly disintegrating tablet containing meclocycline sulfosalicylate is added to water. The tablet disintegrates and a second tablet containing a buffer is added to the solution to raise the pH so that the tetracycline rapidly dissolves.

WORKUP

后处理

additionThe tablet disintegrates and a second tablet containing
additiona buffer is added to the solution
dissolutionrapidly dissolves

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-694cae169bba43bf8a31babb721ca17a
来源数据集: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06683067B2
来源说明: uspto-grants-2004_01

反应 SMILES

[CH3:1][N:2]([C@@H:4]1[C:24]([OH:25])=[C:23]([C:26]([NH2:28])=[O:27])[C:21](=[O:22])[C@:20]2([OH:29])[C@H:5]1[C@@H:6]([OH:33])[C@H:7]1[C:18](=[C:19]2[OH:30])[C:16](=[O:17])[C:15]2[C:14]([OH:31])=[CH:13][CH:12]=[C:11]([Cl:32])[C:10]=2[C:8]1=[CH2:9])[CH3:3].C1C(S(O)(=O)=O)=CC(C(O)=O)=C(O)C=1.C[C@]1(O)[C@@H]2C(=C(O)[C@]3(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@@H]3C2)C(=O)C2C(O)=CC=CC1=2>O>[CH3:1][N:2]([C@@H:4]1[C:24]([OH:25])=[C:23]([C:26]([NH2:28])=[O:27])[C:21](=[O:22])[C@:20]2([OH:29])[C@H:5]1[C@@H:6]([OH:33])[C@H:7]1[C:18](=[C:19]2[OH:30])[C:16](=[O:17])[C:15]2[C:14]([OH:31])=[CH:13][CH:12]=[C:11]([Cl:32])[C:10]=2[C:8]1=[CH2:9])[CH3:3]