Sodium Carbonate → 1-(Diphenylmethyl)-4-[(oxiran-2-yl)methyl]piperazine

Participants

Reaction Steps

After 1-(diphenylmethyl)piperazine (10.0 g) was dissolved in acetonitrile (50 ml), sodium carbonate (6.5 g) and epibromohydrin (6.8 g) were added thereto, and the mixture was heated under reflux for 2.5 hours. Salts were separated by filtration, and then the resulting filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (Wako gel C-200, 200 g) and eluted with a mixed solvent of 99 parts of chloroform and 1 part of methanol to obtain 1-(diphenylmethyl)-4-(1-(2,3-epoxy)propyl)piperazine (5.9 g).

Provenance & Evidence