HCID 69891183, compound → HCID 69891376, compound

HRID 1840882Notes

Reaction equation

HRID 1840882 reaction equation
[CH2:1]([N:10]1[C:19]2[C:14](=[CH:15][C:16]([C:20](=[O:32])[CH:21]=[CH:22][C:23]3[CH:31]=[CH:30][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=3)=[CH:17][CH:18]=2)[C:13]([CH3:34])([CH3:33])[CH2:12][C:11]1=[O:35])CCCCCCCC.BrC1C=CC(C=CC(C2C=C3C(=CC=2)N(C)C(=O)CC3(C)C)=O)=CC=1>>[CH3:1][N:10]1[C:19]2[C:14](=[CH:15][C:16]([C:20](=[O:32])[CH:21]=[CH:22][C:23]3[CH:24]=[CH:25][C:26]([C:27]([OH:29])=[O:28])=[CH:30][CH:31]=3)=[CH:17][CH:18]=2)[C:13]([CH3:33])([CH3:34])[CH2:12][C:11]1=[O:35]

Participants

3

Reactant 2

HCID 69891183HCID 69891183, compound2×HCID 69891638HCID 69891638, compound

Product 1

HCID 69891376HCID 69891376, compoundYield 20%

Procedure

Following a procedure similar to that used for the preparation of Compound 8d but using 6-[3-(4-bromophenyl)-acryloyl]-4,4-dimethyl-1-methyl-3,4-dihydro-1H-quinolin-2-one (Intermediate 7f) as the starting material afforded the title compound as a light yellow solid (20% yield).

Sources & evidence

ORD record
ord-2aed2ccd9c12458aaefbf53bc0b6e0ef
Source dataset
uspto-grants-2004_01
Patent number
US06683092B1

Reaction notes

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