Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1840897Generated: October 31, 2026

alpha-Methylcinnamic acid → (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)(E-2-methyl-3-phenylpropenamide)

https://huagongshe.com/reaction/1840897

Reaction equation

Participants

RoleNameHCIDCharge
Reactantalpha-Methylcinnamic acidHCID 637817—
Reactant(3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochlorideHCID 12494973—
Product(S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)(E-2-methyl-3-phenylpropenamide)HCID 20613771—

Reaction Steps

Prepared as free base by a method analogous to that described in Example 1 from (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-α-methyl-3-phenylpropenoic acid; MS (ES+) 271 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06683090B1
Source datasetuspto-grants-2004_01
ORD IDord-47087588acf9496f9ac60eaeb8b9ab3f
Source noteuspto-grants-2004_01