HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2E)-3-(4-bromophenyl)prop-2-enoic acid → (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(4-bromophenyl)propenamide]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2E)-3-(4-bromophenyl)prop-2-enoic acid | HCID 737158 | — |
| Reactant | (R)-(+)-3-Aminoquinuclidine Dihydrochloride | HCID 12494972 | — |
| Product | (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(4-bromophenyl)propenamide] | HCID 20613761 | — |
Reaction Steps
Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(4-bromophenyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent; MS (ES+) 335, 337 (MH+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683090B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-b2cd7f23c02e49ec9dc24d12864a597d |
| Source note | uspto-grants-2004_01 |