HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-(Trifluoromethyl)cinnamic acid → (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-[E-3-(3-trifluoromethylphenyl)propenamide]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-(Trifluoromethyl)cinnamic acid | HCID 719451 | — |
| Reactant | (R)-(+)-3-Aminoquinuclidine Dihydrochloride | HCID 12494972 | — |
| Product | (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-[E-3-(3-trifluoromethylphenyl)propenamide] | HCID 20613760 | — |
Reaction Steps
Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(3-trifluoromethylphenyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent; MS (ES+) 271 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683090B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-69cfc1ea33cd47e19872f121b55e28ab |
| Source note | uspto-grants-2004_01 |