3-(Pyridin-2-yl)prop-2-enoic acid → HCID 20613736, compound

HRID 1840911Notes

Reaction equation

HRID 1840911 reaction equation
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH2:11])[CH2:4]2.[N:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1/[CH:18]=[CH:19]/[C:20](O)=[O:21]>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:20](=[O:21])/[CH:19]=[CH:18]/[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][N:12]=1)[CH2:4]2

Participants

3

Reactant 2

HCID 53566263-(Pyridin-2-yl)prop-2-enoic acidHCID 12494972(R)-(+)-3-Aminoquinuclidine Dihydrochloride

Product 1

HCID 20613736HCID 20613736, compound

Procedure

Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(2-pyridyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent; MS (ES+) 258 (MH+).

Workup

  1. customPrepared as a free base by a method analogous to
  2. customthe compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent

Sources & evidence

ORD record
ord-6f0852cf52f4491098009fd2872c416b
Source dataset
uspto-grants-2004_01
Patent number
US06683090B1

Reaction notes

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