(R)-(+)-3-Aminoquinuclidine Dihydrochloride → HCID 178520520, compound

HRID 1840916Notes

Reaction equation

HRID 1840916 reaction equation
Cl.Cl.[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH2:11])[CH2:4]2.[NH:12]1[CH:16]=[C:15](/[CH:17]=[CH:18]/[C:19](O)=[O:20])[N:14]=[CH:13]1>>[N:3]12[CH2:10][CH2:9][CH:6]([CH2:7][CH2:8]1)[C@@H:5]([NH:11][C:19](=[O:20])/[CH:18]=[CH:17]/[C:15]1[N:14]=[CH:13][NH:12][CH:16]=1)[CH2:4]2

Participants

3

Reactant 2

HCID 12494972(R)-(+)-3-Aminoquinuclidine DihydrochlorideHCID 178525354HCID 178525354, compound

Product 1

HCID 178520520HCID 178520520, compound

Procedure

Prepared as a free base by a method analogous to that described in Example 1 from (R)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(4-imidazolyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent; MS (ES+) 247 (MH+).

Workup

  1. customPrepared as a free base by a method analogous to
  2. customthe compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent

Sources & evidence

ORD record
ord-787f9d17c468431792a82245f67285a8
Source dataset
uspto-grants-2004_01
Patent number
US06683090B1

Reaction notes

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