HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Furanacrylic acid → (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-furyl)propenamide]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Furanacrylic acid | HCID 643402 | — |
| Reactant | (3S)-1-azabicyclo[2.2.2]octan-3-amine dihydrochloride | HCID 12494973 | — |
| Product | (S)-N-(1-Azabicyclo[2.2.2]oct-3-yl)[E-3-(2-furyl)propenamide] | HCID 20613779 | — |
Reaction Steps
Prepared as a free base by a method analogous to that described in Example 1 from (S)-1-azabicyclo[2.2.2]oct-3-ylamine dihydrochloride and E-3-(2-furyl)propenoic acid; the compound was purified by chromatography on silica gel using ammoniated methanol/chloroform mixtures as the eluent, followed by recrystallization from ethyl acetate/hexane; MS (ES+) 247 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683090B1 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-5eeea2a48aad4348bbcbd8f09047b1b8 |
| Source note | uspto-grants-2004_01 |