HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(Benzyloxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 4-(benzyloxy)benzoate | HCID 299810 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(Benzyloxy)benzoic acid | HCID 73880 | 98.1% |
Reaction Steps
16 mL of a 2N LiOH aqueous solution were added to a solution of 3.0 g (12.5 mmol) of 4-benzyloxy-benzoic acid methyl ester in 50 mL of THF and the mixture was refluxed overnight. The reaction mixture was acidified with HCl 6N and extracted with ethyl acetate affording after filtration and removal of the solvent under reduced atmosphere, 2.8 g (93% yield) of 4-benzyloxy-benzoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683096B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-19a0358be6034e059228d05e1569e5c6 |
| Source note | uspto-grants-2004_01 |