HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-Chloroethane → 4-(2-Chloro-ethoxy)-benzoic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-Chloroethane | HCID 7849 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl 4-hydroxybenzoate | HCID 117640 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | 4-(2-Chloro-ethoxy)-benzoic acid tert-butyl ester | HCID 9837999 | 94% |
Reaction Steps
A mixture containing 0.79 g (4.1 mmol) of 4-hydroxy-benzoic acid tert-butyl ester, 1.13 g (8.14 mmol) of K2CO3 and 1.6 mL (16.3 mmol) of 1-bromo-2-chloro-ethane in 10 mL of isobutyl methyl ketone was refluxed for 5 hours. After filtering, the solvent was removed under reduced pressure affording 0.98 g (94% yield) of 4-(2-chloro-ethoxy)-benzoic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06683096B2 |
| Source dataset | uspto-grants-2004_01 |
| ORD ID | ord-2f4742fea31d4cccbc4278c3db0d39ae |
| Source note | uspto-grants-2004_01 |