Sodium Hydroxide → HCID 11282005, compound

Participants

Reaction Conditions

Reaction Steps

1.05 g (2.33 mmol) of 2-(2-{4-[1-(2-ethoxy-ethyl)-1H-indol-3-yl]-piperidin-1-yl}-ethoxy)-benzoate was dissolved in 30 ml of ethanol. A solution of 0.19 g (4.66 mmol) of sodium hydroxide in 30 ml of water was added to the previous one and the whole mixture was heated at 60° C. for 2 h. After dilution with water and neutralisation with HCl 6N, the aqueous phase was extracted three times with chloroform. The organic solution was washed with brine, dried with sodium sulphate, filtered and evaporated to dryness. The 4.06 g of crude material was recrystallised in acetonitrile affording 2.54 g (64% of yield)of 2-(2-{4-[1-(2-ethoxy-ethyl)-1H-indol-3-yl]-piperidin-1-yl}-ethoxy)-benzoic acid

Provenance & Evidence