Sodium hydride → HCID 23444918, compound

Participants

Reaction Steps

This compound was prepared following the procedure described in Example 138 (part B) starting with 1.6 g (3.3 mmol) of 2-{2-[4-(7-bromo-1H-indol-3-yl)-piperidin-1-yl]-ethoxy}-5-methyl-benzoic acid methyl ester (prepared as in Example 138, part A), 0.17 g (4.2 mmol) of NaH in 60% of mineral oil and 0.45 mL (4 mmol) of bromoethylethyl ether. The crude mixture was hydrolised following the procedure described in Example 138 (part C) and purified by chromatography over silica gel affording 0.26 g (34% of yield) of the desired product.

Provenance & Evidence