L-Alanine → (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

HRID 1840977Notes

Reaction equation

HRID 1840977 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10](Cl)=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:13][C@H:14]([C:16]([OH:18])=[O:17])[CH3:15]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:13][C@H:14]([C:16]([OH:18])=[O:17])[CH3:15])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 5950L-AlanineHCID 27827232-(3,5-Difluorophenyl)acetyl chloride

Product 1

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

Procedure

Using General Procedure II-C, the title compound was prepared from 3,5-difluorophenylacetyl chloride (General Procedure II-B) and L-alanine (Aldrich).

Sources & evidence

ORD record
ord-e71c7ee146864304a471d351d14c80c0
Source dataset
uspto-grants-2004_01
Patent number
US06683075B1

Reaction notes

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