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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1841006Generated: November 2, 2026

(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-delta-valerolactam

https://huagongshe.com/reaction/1841006

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 12135350—
Reactant4-Aminopiperidin-2-oneHCID 19980260—
Product3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)amino-delta-valerolactamHCID 9967722—

Reaction Steps

Following General Procedure A and using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-δ-valerolactam (prepared by the procedure of D. W. Adamson, J. Chem. Soc. 1943, 39), the title compound was prepared.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06683075B1
Source datasetuspto-grants-2004_01
ORD IDord-51126f24b4fb4d8280808b44560da3b1
Source noteuspto-grants-2004_01