1,4-Dioxane hydrochloride → HCID 67118563, compound

HRID 18411Notes

Reaction equation

HRID 18411 reaction equation
[ClH:1].O1CCOCC1.[C:8]12([CH2:18][CH2:19][N:20]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:21]([C@H:23]3[CH2:27][CH2:26][CH2:25][N:24]3C(OC(C)(C)C)=O)=[O:22])[CH2:17][CH:12]3[CH2:13][CH:14]([CH2:16][CH:10]([CH2:11]3)[CH2:9]1)[CH2:15]2>>[ClH:1].[C:8]12([CH2:18][CH2:19][N:20]([CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])[C:21]([C@H:23]3[CH2:27][CH2:26][CH2:25][NH:24]3)=[O:22])[CH2:9][CH:10]3[CH2:11][CH:12]([CH2:13][CH:14]([CH2:16]3)[CH2:15]1)[CH2:17]2

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 67118749HCID 67118749, compound

Product 1

HCID 67118563HCID 67118563, compound

Procedure

Next, 4 N hydrogen chloride/dioxane (20 ml, 81 mmol) was added to (R)-1-(t-butoxycarbonyl)-2-pyrrolidinecarboxylic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide (1.8 g, 4.0 mmol), and then the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated under reduced pressure to give (R)-2-pyrrolidinecarboxylic acid N-[2-(1-adamantyl)ethyl]-N-pentylamide hydrochloride (1.5 g, quantitatively) as an amorphous substance.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-237c4fdbdd534d3aab84b9c996c13ab6
Source dataset
uspto-grants-2010_06
Patent number
US07741346B2

Reaction notes

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