(4-Chlorophenyl)acetic acid → 2-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

HRID 1841147Notes

Reaction equation

HRID 1841147 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 540487372-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 4-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-cf0170cddc2c4bd7a23020e66cbd9b1f
Source dataset
uspto-grants-2004_01
Patent number
US06683075B1

Reaction notes

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