Benzeneacetic acid, 2-fluoro- → 2-[(2-fluorophenyl)acetamido]butyric Acid Iso-butyl Ester

HRID 1841156Notes

Reaction equation

HRID 1841156 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 67979Benzeneacetic acid, 2-fluoro-HCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 536432492-[(2-fluorophenyl)acetamido]butyric Acid Iso-butyl Ester

Procedure

Following General Procedure BI above and using 2-fluorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-17ef28d0a2ae4220a66dd5d3320039e8
Source dataset
uspto-grants-2004_01
Patent number
US06683075B1

Reaction notes

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