2-Methylimidazole → HCID 23444999, compound

HRID 1841200Notes

Reaction equation

Cl.[Cl:2][CH2:3][C:4]1[C:5]([CH3:18])=[N:6][CH:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[C:12]([CH3:17])[CH:11]=2)[CH:9]=1.[CH3:19][C:20]1[NH:21][CH:22]=[CH:23][N:24]=1>>[ClH:2].[CH3:17][C:12]1[CH:11]=[C:10]([C:8]2[CH:9]=[C:4]([CH2:3][N:21]3[CH:22]=[CH:23][N:24]=[C:20]3[CH3:19])[C:5]([CH3:18])=[N:6][CH:7]=2)[CH:15]=[CH:14][C:13]=1[CH3:16]

Participants

Reactant 2

HCID 127492-Methylimidazole

HCID 23444948HCID 23444948, compound

Product 1

HCID 23444999HCID 23444999, compound

Procedure

The title compound, MS: m/e=292.2 (M+H+) was obtained as a beige solid (77% yield) by the reaction of 3-chloromethyl-5-(3,4-dimethyl-phenyl)-2-methyl-pyridine hydrochloride (1:1) with 2-methylimidazole (5 eq.), using sodium hydride (3 eq.) as base followed by formation of the hydrochloride salt.

Sources & evidence

ORD record: ord-de84131b4c8b48d0ab835818110a9228
Source dataset: uspto-grants-2004_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06683097B2

Reaction notes

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